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CLADE™ Sphere - A Chemometric software platform for FTIR data analysis

Transform FTIR spectra into processed data, easily

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CLADE Sphere

CLADE™ Sphere is an intuitive chemometric software platform designed for analytical teams who need fast, reliable, and comprehensive interpretation of FTIR spectral data. It simplifies data processing so that users can obtain end-point results easily and rapidly, without requiring specialised data science support.

Processing of FTIR spectral data should be easy

FTIR spectra of aqueous biologics formulations include huge amount of data and many overlapping signals. Evaluating these spectra manually takes time and effort. Smart chemometric software solutions such as CLADE™ Sphere remove this bottleneck – they allow for fast and reliable data processing with minimal user intervention, providing actionable information for decision making.

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CLADE Sphere

Easily create chemometric models and methods yourself

With a single measurement, the CLADE™ MIRA Analyzer generates a full spectral fingerprint of a sample composition. CLADE™ Sphere is the analytical toolbox that turns that fingerprint into usable insights. It allows easy quantification of formulation composition including APIs and excipients.

1. Easy to use chemometric software

  • Create and run chemometric methods in a guided workflow.
  • Access end-point data for formulation, process, and QC decisions
  • Use proprietary Sphere algorithms and apps to further simplify data processing

2. Built in spectral database SpecHub™

  • Includes digital twins (reference spectra) of 100+ substances relevant to biologics formulations.
  • Supports quantification and identification of formulation components.
  • Reduces calibration effort by using stored spectral information for individual substances.

3. Complete formulation insight from FTIR spectra

  • Use CLADE™ QA Scan for multi-attribute analysis of defined biologics formulations with a two-sample calibration.
  • Use Data Driven for calibration-free analysis of mixtures and buffers with SpecHub-enabled deconvolution.
  • Use Workbench to visualize FTIR spectra and run early data-quality checks.

4. Secure deployment, your way

Choose the hosting environment that fits your needs.

  • On premise hosting: data stays isolated within your organisation (Sphere in a Box).
  • Cloud hosting: share data and evaluations easily across locations and teams.

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How CLADE™ Sphere works

Sphere processes FTIR spectral data from the MIRA Analyzer and applies chemometric modelling to deconvolute complex spectra of biologics samples. The Sphere ecosystem includes a spectral database, proprietary algorithms and apps, so teams can move from spectral fingerprint to end-point result in one software environment.

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CLADE™ Sphere application space

Workflows:

  • Analytical development
  • Formulation development

  • QC

  • Process development

  • Downstream processing

Use cases:

  • Formulation analytics
  • API concentration
  • Excipient testing
  • Surfactant testing
  • Secondary mAbs structure
  • Protein stability

Applications:

  • Raw material control
  • UF/DF monitoring
  • Release testing
  • Buffer quality control
  • Upstream processing
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